Fig. 4
From: Assessment of neuroinflammation in a mouse model of obesity and β-amyloidosis using PET
Obesity and Aβ increase hippocampal TSPO immunoreactivity. a Representative images of TSPO immunoreactivity (red) in the CA1 and dentate gyrus regions of the hippocampus. b Quantification of TSPO immunoreactivity (TSPO-IR) in the CA1 and dentate gyrus regions of control and obese mice infused with either vehicle or Aβ. Obesity combined with Aβ infusion significantly increased hippocampal TSPO immunoreactivity. c Association between hippocampal 11C-PBR-28 accumulation at 3 months and TSPO immunoreactivity. Data presented as mean ± SEM. p < 0.05