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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Oxidative damage and chemokine production dominate days before immune cell infiltration and EAE disease debut

Fig. 3

Semi-quantitative determination of cleaved caspase 9, cleaved caspase 3, cleaved PARP, and cleaved alpha-II spectrin in the brain and spinal cord. The apoptotic markers cleaved caspase 9 (a, n = 6/group), cleaved caspase 3 (b, n = 6/group), and cleaved PARP (89 kDa, c, n = 6/group) are increased in EAE animals only. The N-terminal PARP fragments (55 and 68 kDa, c) are upregulated in 7 DPI animals also. Cleaved alpha-II spectrin (d, n = 6/group) is increased in EAE animals only. α-Tubulin is included as loading control. Mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001 compared to CFA 7 animals

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Journal of Neuroinflammation

ISSN: 1742-2094