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Fig. 11 | Journal of Neuroinflammation

Fig. 11

From: Infliximab reduces peripheral inflammation, neuroinflammation, and extracellular GABA in the cerebellum and improves learning and motor coordination in rats with hepatic encephalopathy

Fig. 11

Infliximab restores motor coordination and the ability to learn the Y maze task in PCS rats. Control (sham) and PCS rats treated with vehicle or infliximab (inflix) were subjected to the beam walking (a) test and the conditional discrimination learning test in the Y maze (b, c). b shows the number of correct trails on each day and c on day 7. Values are the mean ± SEM of 22 sham rats treated with vehicle, sham rats treated with infliximab, 25 PCS rats treated with vehicle and 23 PCS rats treated with infliximab in the beam walking and 7 sham rats treated with vehicle, 7 sham rats treated with infliximab, 6 PCS rats treated with vehicle and 6 PCS rats treated with infliximab in the Y maze task. Two-way ANOVA with repeated measures, followed by Bonferroni post hoc test, was used for statistical analysis in b, variables being group treatment and training day. Values significantly different from control are indicated by asterisks and from PCS rats by a. * p < 0.05; *** p < 0.0001; a p < 0.05

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Journal of Neuroinflammation

ISSN: 1742-2094