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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 1: Frequency, syndrome specificity, influence of disease activity, long-term course, association with AQP4-IgG, and origin

Fig. 7

MOG-specific antibody index (AI). Calculation of the MOG-specific AI in 17 paired CSF/serum samples from 15 MOG-IgG-positive patients did not reveal evidence for intrathecal synthesis of MOG-IgG. The dotted line indicates the upper limit of the reference range (AI = 4). Inset: Reiber diagram [40] demonstrating absence of total IgG intrathecal synthesis in 16 samples from 14 patients and presence of blood-CSF barrier dysfunction in 6/17 samples. QIgG = CSF/serum total IgG ratio; QMOG-IgG = CSF/serum MOG-IgG ratio; QAlb = CSF/serum albumin ratio; Qlim = upper reference range of QIgG (see methods section for details)

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Journal of Neuroinflammation

ISSN: 1742-2094