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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Loss of cerebellar neurons in the progression of lentiviral disease: effects of CNS-permeant antiretroviral therapy

Fig. 5

Breakdown of BBB. Representative slices of single (albumin, a, c, e, g) and double (albumin/GFAP, b, d, f, h) stainings. Note the extensive accumulation of albumin in the parenchyma of the SIV/+AIDS group (e) as surrogate for breakdown of the BBB. BBB breakdown correlates with a rarefication of astroglial structures (f). Extravascular albumin is undetectable in the other groups. Scale bar (in a) 500 μm in a, c, e, g; 62.5 μm in b, d, f, h. ML molecular layer, PL Purkinje layer, GL granular layer, WM white matter

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Journal of Neuroinflammation

ISSN: 1742-2094