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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: The antidepressant-like effects of pioglitazone in a chronic mild stress mouse model are associated with PPARγ-mediated alteration of microglial activation phenotypes

Fig. 1

Effects of pioglitazone at different doses on CMS mice. a Schematic diagram of the experimental design. BW was measured every week (b). The 2.5 mg/kg dose showed the best result in recovering the BW in the CMS mice (c, n = 10). Anhedonia was detected by SP over the course of the 6-week-long experiment (d, e, n = 10). The duration of immobility in the FST (f) and TST (g) increased after CMS induction at the sixth week (n = 8 in both tests). Pioglitazone (2.5 mg/kg) reduced this increase. In the locomotor activity test, pioglitazone improved the spontaneous activity level after CMS induction (h, n = 8). * p < 0.05, * * p < 0.01 vs. Control; # p < 0.05, ## p < 0.01 vs. CMS + Vehicle. Data are expressed as means ± SEM

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