Fig. 8

Schematic diagram illustration of Sino suppressing neuroinflammation via astrocytic mechanisms after cerebral ischemic stroke. Briefly, in ischemic stroke, Sino activates astrocytic DRD2 and induces the up-regulation and nuclear translocation of CRYAB. Then, the enhanced interaction between CRYAB and STAT3 blocks the activation and DNA-binding activity of STAT3, which then reduces the generation of pro-inflammatory cytokines and finally contributes to the anti-inflammatory effect of Sino after cerebral ischemic stroke