Fig. 8

TSPO expression is persistently upregulated in DFP-intoxicated animals that experience more severe seizures. a The geometric mean ratio (dot) of TSPO labeling with 95 % confidence interval (bar) in DFP-exposed rats relative to VEH controls. Confidence intervals not overlapping y = 1 (gray horizontal bar) indicate a significant difference relative to VEH (p < .05). The data presented in the left panel include all TSPO phenotypes (n = 9 DFP-exposed animals as shown in Fig. 7), while the data presented in the right panel exclude the three DFP-intoxicated animals expressing the alternate TSPO phenotypes, as shown in Fig. 7. b The predominant TSPO expression phenotype is highly associated with more severe seizure behavior as indicated by higher seizure scores (p < .01 as determined using the Wilcoxon signed rank test)