Fig. 3

Neuroinflammation induced by i.p. injections of LPS had no effect on extracellular acidity in the CA1 region. a Schema of the experiment. A pH-sensitive micropipette was sequentially positioned at distances varying from +200 to −180 μm from the slice surface, in steps of 20 μm, at which pHo levels were measured. b Time course of pHo changes during a representative experiment. The micropipette was moved to a new position every 5 s. pHo levels changed during the movements but were stable between the movements. Insert: part of the curve at a higher magnification. At each electrode position, pHo levels were averaged for the stable period (between the arrows in the insert). c Averaged data for the pHo profiles in slices from the saline- and LPS-injected mice. No statistical difference was observed between the saline and LPS groups. LPS: n = 10; saline: n = 10