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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Appearance of claudin-5+ leukocytes in the central nervous system during neuroinflammation: a novel role for endothelial-derived extracellular vesicles

Fig. 1

CLN-5+ leukocytes are present in the CNS during early EAE. z-stack confocal images acquired from the same spinal cord cryosection of a WT mouse at D9 EAE are shown. a Immunostaining of TJ protein CLN-5 (green) and CD31 (red) to identify endothelial cells, showing CLN-5 is present on both leukocytes and at endothelial junctions. b DRAQ5 staining (blue) highlights the cellularity associated with CNS-infiltrating leukocytes, revealing CLN-5+ leukocytes (green) comprise a subset of invading cells. c Immunostaining of TJ protein CLN-5 only; arrows (yellow) indicate some CLN-5+ leukocytes are associated with areas of discontinuity of CLN-5 junctional staining. Leukocyte-associated CLN-5 immunoreactivity displays a punctate appearance

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Journal of Neuroinflammation

ISSN: 1742-2094