Fig. 3

T ₂-weighted MRI following injection of BFP-MSC or IL13-MSC on the right side of the splenium in CPZ-treated mice. a Left side: dot plot showing T ₂-relaxation times of the whole splenium of the corpus callosum (CC) in healthy control mice (n = 16), in CPZ-treated mice (CPZ control, n = 17), in BFP-MSC grafted CPZ-treated mice (CPZ + BFP-MSC, n = 20) and in IL13-MSC grafted CPZ-treated mice (CPZ + IL13-MSC, n = 24). Each data point corresponds to the value obtained from an individual mouse of one of the three independent experiments (described in Table 1). The mean of each independent experiment is represented by a horizontal line. Right side: representative MRI image demonstrating intensity alterations in the splenium for each group (area indicated by arrows). b Left side: dot plot showing T ₂-relaxation times of the whole external capsule (EC) for each experimental group. The mean of each independent experiment is represented by a horizontal line. Right side: representative MRI image demonstrating intensity alterations in the EC for each group (area indicated by the arrows). c Dot plot showing T ₂-relaxation times of the right side of the splenium for each experimental group. The mean of each independent experiment is represented by a horizontal line. d Dot plot showing T ₂-relaxation times of the left side of the splenium for each experimental group. The mean of each independent experiment is represented by a horizontal line. For all dot plots, significant differences versus the CPZ control group are indicated with one (p value <0.05), two (p value ≤0.01) or three (p value ≤ 0.001) asterisks. Data points indicated in red on (a, b, c and d) correspond with the MRI images provided in (a and b) and the histological images shown in Fig. 4a