Intracerebral transplantation of interleukin 13-producing mesenchymal stem cells limits microgliosis, oligodendrocyte loss and demyelination in the cuprizone mouse model

Table 1 Experimental outline of the three comparative cell grafting experiments performed in the cuprizone (CPZ) mouse model

Exp.	Mouse strain	Cell graft	Healthy control	CPZ control	CPZ + BFP-MSC	CPZ + IL13-MSC
1	C57BL/6 wt	BFP-MSC IL13-MSC	–	–	n = 5	n = 7
2	C57BL/6 wt	BFP-MSC IL13-MSC	n = 10	n = 10	n = 10	n = 10
3	C57BL/6 CX₃CR1^eGFP/+CCR2^RFP/+ tg	BFP-MSC IL13/BFP-MSC^a	n = 6	n = 6	n = 5	n = 7
Total number of mice			n = 16	n = 16	n = 20	n = 24

Exp experiment, wt wild type, tg transgenic, MSC mesenchymal stem cell, BFP-MSC blue fluorescent protein-expressing MSC, IL13-MSC interleukin 13-expressing MSC, IL13/BFP-MSC IL13 + BFP-expressing MSC, n number of mice
^aTo avoid confusion, both IL13-producing cell lines, IL13- and IL13/BFP-MSC, will be referred to as IL13-MSC further in text

ISSN: 1742-2094