Fig. 2

a Chronic demyelination scores in spinal cords of different transgenic mice compared to wild-type mice. Morphological analysis of spinal cords from mice sacrificed at 45 dpi was performed on 12 to 15 sections per mouse. Each quadrant from every coronal section of each mouse was graded for demyelination. Percentage of spinal cord quadrants examined with the pathologic abnormality scores are shown. The number of mice analyzed in the experiment is listed beside each bar. b Percentage of animals positive for demyelination. Number of animals positive for demyelination based on morphological analysis are plotted as percentage positive for demyelination in each group. One hundred percent of mice in the susceptible phenotype showed demyelination in the sections tested, whereas mice with competent immune system did not show any demyelination