Fig. 3

Pathology scores of the brain. Pathologic analysis of brain areas (cerebellum, brain stem, cortex, hippocampus, striatum, corpus callosum, and meninges) at 7 days (a–g) and 45 days (h–n) following TMEV infection (dpi). Mouse strains shown are Aβ⁰.β2m⁰.Hβ2m⁺.A11⁺ (red open circle) and Aβ⁰.β2m⁰.Hβ2m⁺.B27⁺ (blue open square). Pathologic qualitative scores from 0 to 4 are described in the materials and methods. Each symbol represents one mouse. There were no differences between the two strains in the distribution of brain pathology at 7 days after infection (a–g). At the 45-day time point, there was less brain pathology in Aβ⁰.β2m⁰.Hβ2⁺.B27⁺ mice as compared to Aβ⁰.β2m⁰.Hβ2m⁺.A11⁺mice (P = 0.027, rank sum test; h–n)