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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Inhibition of STAT3- and MAPK-dependent PGE2 synthesis ameliorates phagocytosis of fibrillar β-amyloid peptide (1-42) via EP2 receptor in EMF-stimulated N9 microglial cells

Fig. 6

Involvement of EP2 activity in the restoration of impaired phagocytosis of 647-fAβ42 in EMF-stimulated N9 cells. N9 cells were pretreated with or without PG receptor EP1 antagonist GW848687X (5 μM), EP2 antagonist AH6809 (10 μM), EP3 antagonist L-798106 (10 μM), and EP4 antagonist GW627368X (10 μM). a Normalized average fluorescence intensity of 647-fAβ42 ingested per group 12 h after EMF exposure estimated using a flow cytometer and a confocal microscope. *P < 0.05 vs the sham-exposed control group; # P < 0.05 vs the EMF-exposed group. b Microscopy images of 647-fAβ42 phagocytosis in N9 cells pretreated with or without AH6809 12 h after EMF exposure. Scale bar = 20 μm

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Journal of Neuroinflammation

ISSN: 1742-2094