Fig. 8

NaB treatment increases IGF-1 levels in peripheral tissues but not brain at 5 days post stroke. IGF-1 levels were determined by ELISA from cortex + striatum (a), serum (b), liver (c), and spleen (d) samples collected at 5d post MCAo. a IGF-1 levels are significantly elevated in the ischemic hemisphere; however, there is no difference in IGF-1 level between treatment groups in either the ischemic or non-ischemic hemisphere. ***p < 0.001 main effect of hemisphere. b–d Post-stroke NaB treatment increased serum (b), liver (c), and spleen (d) levels of IGF-1 as compared to post-stroke vehicle-treated group. **p < 0.01; unpaired t test. All graphs represent mean ± S.E.M. n = 6 in each group. ICS ischemic cortex and striatum, NICS non-ischemic cortex and striatum