Fig. 5From: Cell cycle inhibition reduces inflammatory responses, neuronal loss, and cognitive deficits induced by hypobaria exposure following traumatic brain injuryHypobaria exposure upregulates the expression of CDK4 in the ipsilateral cortex and hippocampus at 30 days after TBI. a Representative immunofluorescent staining for CDK4 (green) and DAPI (blue). b, c Quantification of pixel intensity for CDK4 revealed significant increases in the TBI + Veh + HB group in contrast to the TBI-alone tissue. A significant decrease of CDK4 expression was observed in the CR8 treatment group in comparison to the TBI/Veh/HB group. N = 4 (sham), 6 (TBI), 6 (TBI/Veh/HB), 6 (TBI/CR8/HB). *p < 0.05, TBI vs. sham injury; $ p < 0.05, TBI/CR8/HB vs. TBI; # p < 0.05, ### p < 0.001, TBI/HB/CR8 vs. TBI/Veh/HB. d Some of the CDK4+ cells (green) in the injured cortex were co-labeled with NeuN-expressing neurons (red; DAPI, blue). Scale bar = 50 μm in a and 25 μm in d Back to article page