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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Cell cycle inhibition reduces inflammatory responses, neuronal loss, and cognitive deficits induced by hypobaria exposure following traumatic brain injury

Fig. 5

Hypobaria exposure upregulates the expression of CDK4 in the ipsilateral cortex and hippocampus at 30 days after TBI. a Representative immunofluorescent staining for CDK4 (green) and DAPI (blue). b, c Quantification of pixel intensity for CDK4 revealed significant increases in the TBI + Veh + HB group in contrast to the TBI-alone tissue. A significant decrease of CDK4 expression was observed in the CR8 treatment group in comparison to the TBI/Veh/HB group. N = 4 (sham), 6 (TBI), 6 (TBI/Veh/HB), 6 (TBI/CR8/HB). *p < 0.05, TBI vs. sham injury; $ p < 0.05, TBI/CR8/HB vs. TBI; # p < 0.05, ### p < 0.001, TBI/HB/CR8 vs. TBI/Veh/HB. d Some of the CDK4+ cells (green) in the injured cortex were co-labeled with NeuN-expressing neurons (red; DAPI, blue). Scale bar = 50 μm in a and 25 μm in d

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