Fig. 5
From: Pro-epileptogenic effects of viral-like inflammation in both mature and immature brains
Effects of PIC and minocycline treatments on epileptogenesis. Kindling progression parameters 24 h after intrahippocampal injection (saline vs. PIC 10 μg/rat) and the last minocycline intraperitoneal injection (Saline + minocycline vs. PIC 10 μg/rat + minocycline) and afterdischarge (AD) properties at retest, 24 h after kindling onset in P14 (a) and in P75 rats (b). Total number of stages 4-5 seizures and number of stimulations to achieve stage 4–5 seizure in P14 (a) and P75 rats (b). Afterdischarge threshold (ADT), afterdischarge duration (ADD), and seizure score at retest in P14 (a) and P75 rats (b) 24 h after kindling onset. Data are presented as mean ± SEM. *p < 0.05 vs. saline (Mann-Whitney test)