Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer’s disease

Moussa, Charbel; Hebron, Michaeline; Huang, Xu; Ahn, Jaeil; Rissman, Robert A.; Aisen, Paul S.; Turner, R. Scott

doi:10.1186/s12974-016-0779-0

Journal of Neuroinflammation

Table 2 Summary of statistical tests of null changes between baseline and 52 weeks and tests of null differences at baseline using all detected molecules in plasma of patients treated with placebo (N = 19) or resveratrol (N = 19)

From: Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer’s disease

Analytes	Between baseline and 52 weeks					At baseline
	Paired t test		Unpaired t test	Wilcoxon signed rank test		Baseline: active vs placebo
	Placebo	Active		Placebo	Active	Unpaired t test (unequal)	Unpaired t test (equal)	Wilcoxon signed rank test
MMP-9	0.1477	0.8332	0.7577	0.2412	0.6319	0.8751	0.8737	1.0000
MMP-3	0.3193	0.0062**	0.065	0.3575	0.0102*	0.6911	0.6882	0.9311
MMP-2	0.5783	0.1647	0.1671	0.7148	0.177	0.8828	0.8828	0.8509
MMP-10	0.4557	0.0243*	0.0106*	0.5417	0.0353	0.9415	0.9410	0.6807
MMP-12	0.457	0.9138	0.4917	0.4631	0.9306	0.3667	0.3787	0.3310
MMP-13	0.1897	0.3379	0.0489*	0.3575	0.421	0.0598	0.0722	0.0938
MMP-1	0.7483	0.9518	0.7139	0.4263	0.8129	0.1371	0.1264	0.1059
FGF-2	0.6374	0.9743	0.6426	0.7002	0.6701	0.6751	0.6774	0.5508
G-CSF	0.3334	0.4526	0.2682	0.4131	0.5703	0.2042	0.2422	0.4195
MDC	0.7177	0.8208	0.1778	0.7148	0.7605	0.0458	0.0566	0.0678
PDGF-AA	0.8196	0.5719	0.3956	0.583	0.5421	0.9883	0.9886	0.8957
PDGF-AB/BB	0.2176	0.889	0.998	0.3258	0.9246	0.6349	0.6261	0.7881
IL-8	0.2096	0.7207	0.0322*	0.5416	0.9794	0.9648	0.9648	0.6450
EGF	0.5238	0.5667	0.7799	0.4263	0.8564	0.8870	0.8815	0.7234
Eotaxin	0.5987	0.0518	0.0697	0.5016	0.0611	0.7968	0.8017	0.8212
GM-CSF	0.6863	0.4321	0.3562	0.8501	0.4648	0.5001	0.4856	0.6638
Fractalkine	0.8863	0.8397	0.8579	0.9032	0.9245	0.4541	0.4543	0.8641
IFNα2	0.8981	0.8459	0.9661	1	0.9622	0.8727	0.8729	0.6194
IFNy	0.8316	0.438	0.8992	0.7148	0.463	0.8357	0.8406	0.8745
GRO	0.3481	0.6638	0.8992	0.2958	0.9622	0.9496	0.9478	0.5825
IL-12P40	0.6103	0.0485*	0.6473	0.9102	0.0781	0.2033	0.1897	0.3816
IL-12P70	0.5558	0.0404*	0.8159	0.7344	0.0424*	0.6327	0.6141	0.7730
sCD40L	0.3657	0.793	0.9062	0.3258	0.9653	0.6623	0.6483	0.8802
IL-17A	0.3792	0.7593	0.1786	0.4752	0.8158	0.3152	0.2696	0.6923
IL-1RA	0.0462*	0.4993	0.6706	0.0137*	0.7615	0.0880	0.0802	0.0317
IL-2	0.8926	0.0311*	0.9868	1	0.0547	0.2103	0.2015	0.2712
IP-10	0.1619	0.0673	0.0975	0.1353	0.0742	0.3900	0.3918	0.8509
MCP-1	0.5574	0.0637	0.2533	0.7148	0.0523	0.8650	0.8650	0.9864
MIP-1a	0.3696	0.2241	0.588	0.3594	0.1289	0.0175	0.0247	0.0440
MIP-1b	0.3694	0.6581	0.5786	0.3652	0.8469	0.7722	0.7632	0.8401
RANTES	0.8545	0.0335*	0.2919	0.9515	0.0366*	0.9889	0.9889	0.9699
TNFα	0.0221*	0.2091	0.7741	0.0161*	0.463	0.4081	0.4298	0.5861

Indicated in bold typeface represents significant associations (at level 0.05) after the Benjamini–Hochberg correction
*p<0.05
**p<0.1

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ISSN: 1742-2094

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