Fig. 2

APAP attenuated behavioural performance after exposure to LPS in mice. a Spatial learning in the MWM on days −3, −2 and −1. Average escape latency (s) is shown for the three training sessions in the maze. b Swimming speed during probe testing on day 1. c Platform-site crossings during probe testing on day 1. e Time travelled in the target quadrant during probe testing on day 1. f Percentage of distance travelled in the target quadrant during probe testing on day 1. d Latency to the platform during spatial working memory testing on days 1, 2 and 3. g–j Representative trajectories of mice from each experimental group during probe testing in which the hidden platform was removed. The circle represents the previous location of the platform. Data are expressed as the mean ± SE (n = 20). *P < 0.05, ***P < 0.001 vs. CON group; ^## P < 0.01, ^### P < 0.001 vs. LPS group; &&&P < 0.001 vs. training session 1 in day −3. APAP acetaminophen, aCSF artificial cerebrospinal fluid, LPS lipopolysaccharide, SE standard error