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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Enhanced neuroinflammation mediated by DNA methylation of the glucocorticoid receptor triggers cognitive dysfunction after sevoflurane anesthesia in adult rats subjected to maternal separation during the neonatal period

Fig. 8

TSA attenuated sevoflurane-induced cognitive impairment in adult rats with neonatal maternal separation. a Schematic illustration of the experimental timeline. MS maternal separation, Sev anesthesia with 3% sevoflurane for 2 h, TSA trichostatin A, MWM Morris water maze, CFC context fear conditioning. b TSA group rats had a shorter escape latency than DMSO group rats on the third and fourth days after sevoflurane anesthesia. There was a statistically significant interaction of time and group between the different groups (* P < 0.05). Analysis was performed by repeated-measures two-way ANOVA. c The time in the target quadrant in the TSA group was more than that in the DMSO group by the MWM probe test. d There was no significant difference in the number of crossings of the platform area between the two groups of rats. e TSA group rats exhibited increased freezing to context relative to DMSO group rats. * P < 0.05, ** P < 0.01 versus DMSO. Error bars represent the means ± SD (n = 10). Statistical analyses were performed with Student’s two-sample t test

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Journal of Neuroinflammation

ISSN: 1742-2094