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Table 1 Standard serum and CSF parameters in HC and CIS/eRRMS

From: BAFF Index and CXCL13 levels in the cerebrospinal fluid associate respectively with intrathecal IgG synthesis and cortical atrophy in multiple sclerosis at clinical onset

  HC CIS/eRRMS
Gender (F/M) 13/4 26/14
Age at LP (years) 43.2 ± 9.2 37.8 ± 10.0
Disease duration (years) n.a. 0.5 ± 0.9
CSF [Alb] (mg/dL) 17.0 ± 5.1 22.5 ± 9.8
Serum [Alb] (mg/dL) 4370.6 ± 379.0 4260.0 ± 333.6
QAlb (10−3) 3.9 ± 1.2 5.3 ± 2.3*
CSF [IgG] (mg/dL) 2.2 ± 0.9 3.7 ± 1.8***
Serum [IgG] (mg/dL) 1141.2 ± 215.2 1042.0 ± 197.7
QIgG (10−3) 1.9 ± 0.6 3.6 ± 1.7****
IgG Index 0.5 ± 0.1 0.7 ± 0.3***
IgG Loc (mg/dL) 0.1 ± 0.3 5.9 ± 10.2*
IgIF (%) 0 ± 0 11 ± 17*
IgGOB (%) 0% 65%****
Leukocyte counts (/μL) 2.1 ± 1.1 6.9 ± 7.7*
  1. Disease duration was defined as the time between clinical disease onset and lumbar puncture. For gander, IgIF% and IgGOB chi-square test was applied. For all the other variables, a t test was performed
  2. HC healthy controls, CIS/eRRMS CIS suggestive of MS or early RRMS, LP lumbar puncture, n.a. not applicable, Csf cerebrospinal fluid, S serum, IgGOB IgG oligoclonal bands
  3. *p < 0.05; **p < 0.01; ***p < 0.005; ****p < 0.001