Absence of system xc − on immune cells invading the central nervous system alleviates experimental autoimmune encephalitis

Table 2 Relative expression values of proteins possibly involved in regulating xCT transcription and xCT expression in NAWM samples of controls and MS patients

	Sample reference	xCT*	ATF4/actin	p-GSK3β	p-NF-κB(p65)/NF-κB	NF-κB(p65)/actin	iNOS/actin*
Controls	3204	0.73	0.396	⁻	0.334	0.782	0.037
	3529	1.18	0.714	+	0.533	0.954	0.069
	3531	1.31	1.050	⁻	0.378	1.060	0.021
	3540	0.75	0.959	⁻	0.299	3.390	0.110
	3543	1.03	1.05	⁻	0.358	1.090	0.232
MS patients	2946	2.63	0.972	⁻	0.291	0.952	0.273
	3010	4.05	3.590	++	0.979	0.520	0.136
	3161	0.94	0.914	+	0.266	2.140	0.227
	3163	2.50	0.668	⁻	0.317	0.950	0.595
	3185	1.22	2.810	⁻	0.286	1.600	1.310
	3816	1.73	0.726	+	1.166	0.491	0.143
	3867	4.13	0.616	⁻	0.409	0.856	0.123
	4107	1.14	0.553	⁻	0.581	0.777	0.122

ATF4 activating transcription factor 4, iNOS nitric oxide synthase, MS multiple sclerosis, NAWM normal appearing white matter, NF-κB nuclear factor-κB, p-GSK3β phosphorylated glycogen synthase kinase 3β, p-NF-κB phosphorylated nuclear factor-κB; sample reference, numbers given by Human Brain and Spinal Fluid Resource Center in Los Angeles
*comparison between control and MS patients, Mann-Whitney U test, p < 0.05

ISSN: 1742-2094