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Table 2 Relative expression values of proteins possibly involved in regulating xCT transcription and xCT expression in NAWM samples of controls and MS patients

From: Absence of system xc on immune cells invading the central nervous system alleviates experimental autoimmune encephalitis

  Sample reference xCT* ATF4/actin p-GSK3β p-NF-κB(p65)/NF-κB NF-κB(p65)/actin iNOS/actin*
Controls 3204 0.73 0.396 0.334 0.782 0.037
  3529 1.18 0.714 + 0.533 0.954 0.069
  3531 1.31 1.050 0.378 1.060 0.021
  3540 0.75 0.959 0.299 3.390 0.110
  3543 1.03 1.05 0.358 1.090 0.232
MS patients 2946 2.63 0.972 0.291 0.952 0.273
  3010 4.05 3.590 ++ 0.979 0.520 0.136
  3161 0.94 0.914 + 0.266 2.140 0.227
  3163 2.50 0.668 0.317 0.950 0.595
  3185 1.22 2.810 0.286 1.600 1.310
  3816 1.73 0.726 + 1.166 0.491 0.143
  3867 4.13 0.616 0.409 0.856 0.123
  4107 1.14 0.553 0.581 0.777 0.122
  1. ATF4 activating transcription factor 4, iNOS nitric oxide synthase, MS multiple sclerosis, NAWM normal appearing white matter, NF-κB nuclear factor-κB, p-GSK3β phosphorylated glycogen synthase kinase 3β, p-NF-κB phosphorylated nuclear factor-κB; sample reference, numbers given by Human Brain and Spinal Fluid Resource Center in Los Angeles
  2. *comparison between control and MS patients, Mann-Whitney U test, p < 0.05