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Table 5 Significant relationships between major white matter tracts integrity and interleukin-1 beta genotype groups or cognitive test scores

From: Genetic effect of interleukin-1 beta (C-511T) polymorphism on the structural covariance network and white matter integrity in Alzheimer’s disease

  Fractional anisotropy MMSE CASI total scores CASI EFT
Major white matter tract fractional anisotropy C-carrier TT C-carrier TT C-carrier TT C-carrier TT
Forceps major 0.47(0.04) 0.48(0.05) 0.25* 0.40* 0.29** 0.34 0.35** 0.40*
Forceps minor 0.35(0.03) 0.35(0.03) 0.26* 0.48* 0.28** 0.44* 0.34** 0.52*
Anterior thalamic radiation 0.60(0.06) 0.61(0.06) 0.22* 0.48* 0.24* 0.42* 0.30** 0.48*
Corticospinal tract 0.99(0.06) 0.99(0.06) 0.37** 0.10 0.39** 0.07 0.44** 0.17
Cingulum 0.68(0.06) 0.68(0.07) 0.29** 0.41* 0.32** 0.36 0.32** 0.43*
Cingulum (hippocampus) 0.58(0.07) 0.59(0.06) 0.41** 0.18 0.45** 0.16 0.38** 0.17
Inferior fronto-occipital fasciculus 0.74(0.05) 0.74(0.06) 0.22* 0.29 0.26* 0.24 0.34** 0.29
Inferior longitudinal fasciculus 0.74(0.05) 0.75(0.05) 0.26* 0.31 0.30** 0.29 0.37** 0.32
Superior longitudinal fasciculus 0.63(0.05) 0.63(0.06) 0.20* 0.24 0.23* 0.22 0.27** 0.29
Uncinate fasciculus 0.68(0.05) 0.68(0.04) 0.26* 0.20 0.28** 0.13 0.30** 0.17
Superior longitudinal fasciculus (temporal part) 0.90(0.08) 0.89(0.09) 0.14 0.26 0.18 0.27 0.24* 0.32
  1. Data of Fractional Anisotropy represent mean (standard deviation), MMSE Mini-Mental State Examination scores, CASI Cognitive Ability Screening Instrument, EFT executive function test, EFT Sum of attention, verbal fluency, abstract thinking, and mental manipulation sub-domain scores of the CASI, TT T homozygotes
  2. Numbers indicate mean and standard deviation or Pearson correlation coefficient; *p < 0.05 **p < 0.01