Genetic effect of interleukin-1 beta (C-511T) polymorphism on the structural covariance network and white matter integrity in Alzheimer’s disease

Table 5 Significant relationships between major white matter tracts integrity and interleukin-1 beta genotype groups or cognitive test scores

	Fractional anisotropy		MMSE		CASI total scores		CASI EFT
Major white matter tract fractional anisotropy	C-carrier	TT	C-carrier	TT	C-carrier	TT	C-carrier	TT
Forceps major	0.47(0.04)	0.48(0.05)	0.25*	0.40*	0.29**	0.34	0.35**	0.40*
Forceps minor	0.35(0.03)	0.35(0.03)	0.26*	0.48*	0.28**	0.44*	0.34**	0.52*
Anterior thalamic radiation	0.60(0.06)	0.61(0.06)	0.22*	0.48*	0.24*	0.42*	0.30**	0.48*
Corticospinal tract	0.99(0.06)	0.99(0.06)	0.37**	0.10	0.39**	0.07	0.44**	0.17
Cingulum	0.68(0.06)	0.68(0.07)	0.29**	0.41*	0.32**	0.36	0.32**	0.43*
Cingulum (hippocampus)	0.58(0.07)	0.59(0.06)	0.41**	0.18	0.45**	0.16	0.38**	0.17
Inferior fronto-occipital fasciculus	0.74(0.05)	0.74(0.06)	0.22*	0.29	0.26*	0.24	0.34**	0.29
Inferior longitudinal fasciculus	0.74(0.05)	0.75(0.05)	0.26*	0.31	0.30**	0.29	0.37**	0.32
Superior longitudinal fasciculus	0.63(0.05)	0.63(0.06)	0.20*	0.24	0.23*	0.22	0.27**	0.29
Uncinate fasciculus	0.68(0.05)	0.68(0.04)	0.26*	0.20	0.28**	0.13	0.30**	0.17
Superior longitudinal fasciculus (temporal part)	0.90(0.08)	0.89(0.09)	0.14	0.26	0.18	0.27	0.24*	0.32

Data of Fractional Anisotropy represent mean (standard deviation), MMSE Mini-Mental State Examination scores, CASI Cognitive Ability Screening Instrument, EFT executive function test, EFT Sum of attention, verbal fluency, abstract thinking, and mental manipulation sub-domain scores of the CASI, TT T homozygotes
Numbers indicate mean and standard deviation or Pearson correlation coefficient; *p < 0.05 **p < 0.01

ISSN: 1742-2094