Fig. 6
From: Microglia P2Y6 receptor is related to Parkinson’s disease through neuroinflammatory process
Activation of P2Y6R by UDP is partially dependent on ERK1/2 phosphorylation. a Representative western blots showing that ERK1/2 phosphorylation was stimulated in a time-dependent manner by UDP. b Representative western blots and RT-PCR showing that COX-2 protein and MIP-2 mRNA levels were decreased in UDP-stimulated BV-2 cells pretreated with U0126 (ERK1/2 inhibitor). c ELISA showing that MIP-2 secretion level was decreased in UDP-stimulated BV-2 cells pretreated with U0126. SB (SB203580, P38 inhibitor), SP (SP600125, JNK1/2 inhibitor). Data are shown as the mean ± SD of three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001 vs Con, ## p < 0.01, ### p < 0.001 vs LPS