Fig. 6
From: Everolimus is better than rapamycin in attenuating neuroinflammation in kainic acid-induced seizures
A summary of the effects of rapamycin and everolimus on signaling pathways involved in neuroinflammation and seizure. The direct inhibition of mTORC1 and mTORC2 by rapamycin and everolimus is from previous studies. The other effects of rapamycin and everolimus depicted in this figure are based on this study. E everolimus, ERK extracellular signal-regulated kinases, iNOS inducible nitric oxide synthase, KA kainic acid, LPS lipopolysaccharide, mTORC1/2 mechanistic target of rapamycin complex 1/2, NO nitric oxide, R rapamycin, Rheb Ras homolog-enriched in brain, TSC1/2 tuberous sclerosis complex 1/2