Fig. 11
TOCI. An illustration demonstrates the cellular and molecular events associated with PWMD in the septic developing brain. Microglia are activated after LPS intraperitoneal injection and release proinflammatory cytokine IL-1β, which inhibits the generation of NFL, NFM, and NFH in the axon through its IL-1R1 via p38-MAPK signaling pathway. This suppresses axon development and contributes to axonal hypomyelination in septic neonatal brain. Moreover, the synaptogenesis of neurons involved in this process is ultimately affected