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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Microglia-derived IL-1β contributes to axon development disorders and synaptic deficit through p38-MAPK signal pathway in septic neonatal rats

Fig. 2

Electron micrographs show thinner axons and aberrant Ranver node in PWM of 28-day rats. Electron microscopic images of PWM in cross-sections are shown at different magnifications. a Myelinated axons are regularly packed in the control with intact two oligodendrocytes (asterisks) under low magnification. b Note drastic reduction in myelinated axons at 28 days after LPS injection. Normal Oligodendrocyte (asterisk)) appears less. c Myelinated axons in the control. Note the thick myelin sheath under high magnification. d Note drastic reduction in myelinated axons at 28 days after LPS injection and some are distorted (asterisk). Many unmyelinated axons (UA) are seen. e Normal node of Ranvier (arrow) in the control. f Disrupted node of Ranvier (arrows) at 28 days after LPS injection. g Disrupted axon (asterisk) and myelin sheath at 28 days after LPS injection. h Disrupted myelin sheath (arrows) at 28 days after LPS injection. Scale bars: a 2 μm; b 5 μm; c 1 μm; d 500 nm; e–f 0.5 μm; g 0.2 μm; h 0.5 μm

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Journal of Neuroinflammation

ISSN: 1742-2094