Fig. 1

Sodium butyrate treatment reduces hypoxia-ischemia- induced brain damage in neonates. Seven-day-old rats (PND7) were subjected to hypoxia-ischemia followed by 6 days of recovery. SB or vehicle was administered directly after the onset of HI and for 5 consecutive days. a Brain coronal sections from sham control animals and from animals 6 days after hypoxia-ischemia (with or without SB treatment) were stained with hematoxylin-eosin (HE). b Lower panel represents magnification (100×) of the ipsilateral hemisphere area (marked with rectangles in a). Note the loss of neurons and signs of cerebral edema in the cortex of ipsilateral hemisphere. Sodium butyrate administration provided almost complete neuroprotection in comparison with non-treated animals. Photomicrographs are representative of observations made from five animals per group