Fig. 10

The effect of SB treatment on caspase-3 activity in the brain after neonatal HI. Seven-day-old rats (PND7) were subjected to hypoxia-ischemia followed by 24 or 48 h of recovery. SB or vehicle was administered directly after the onset of HI and for 2 consecutive days. Bar graphs represent statistical analysis of fluorescence units estimated in four experimental groups: vehicle control (C), SB-treated control (C + SB), vehicle-treated hypoxia-ischemia (HI), and SB-treated hypoxia-ischemia (HI + SB). SB application had no effect on the HI-induced activation of caspase-3 in the HI ipsilateral hemispheres. The values represent means ± SD from five animals. The one-way ANOVA and Bonferroni test: *p < 0.05, ***p < 0.001, ****p < 0.0001. C control, ipsi ipsilateral, contra contralateral