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Table 1 Demographic and clinical characteristics of nAMD patients and controls from secreted cytokines analysis (experiment 2)

From: Peripheral blood mononuclear cells from neovascular age-related macular degeneration patients produce higher levels of chemokines CCL2 (MCP-1) and CXCL8 (IL-8)

  All
(n = 103)
Controls
(n = 28)
nAMD
(n = 75)
P value
nAMD vs control
Age (median (range)), years 77.2 (57–93) 74.5 (59–92) 78.1 (57–93) 0.066a
Female sex (number (%)) 58 (56) 14 (50) 44 (59) 0.505b
Family history of AMD (number (%)) 25 (24) 4 (14) 21 (28) 0.202b
Cardiovascular disease (number (%)) 27 (26) 6 (21) 21 (28) 0.621b
Hypertension (number (%)) 62 (60) 12 (43) 50 (67) 0.065b
Diabetes (number (%)) 12 (12) 1 (4) 11 (15) 0.175b
Body mass index (mean ± SD) 25.8 (4.0) 25.2 (3.8) 26.1 (4.0) 0.318c
Smoking status     0.883b
 Non-smoker (number (%)) 40 (39) 12 (43) 28 (37)  
 Former smoker (number (%)) 54 (52) 13 (46) 41 (55)  
 Current smoker (number (%)) 8 (8) 2 (7) 6 (8)  
Taking medication for CVD (number (%)) 73 (71) 17 (61) 56 (75) 0.320b
Vitamin supplementation (number (%)) 21 (20) 2 (7) 19 (25) 0.055b
Taking low-dose aspirin (number (%)) 33 (32) 3 (11) 30 (40) 0.008 b
  1. Italics P < 0.05
  2. SD standard deviation
  3. aMann Whitney U test
  4. bPearson’s chi-square test
  5. cIndependent samples t test