|
Variables
|
Normothermia (NT) mean (SD)
|
Hypothermia (HT) mean (SD)
|
p Value
|
|---|
|
Post-natal age (h)
|
22.9 (0.9)
|
23.2 (0.8)
|
0.84
|
|
Body weight (g)
|
1583 (105)
|
1577 (91)
|
0.79
|
|
HR (bpm)
|
|
Baseline
|
156 (12)
|
156 (12)
|
0.10
|
|
End of insult
|
219 (55)
|
199 (55)
|
0.06
|
|
2–26 h after time zero
|
162 (15)
|
132 (10)
|
0.10
|
|
48 h after time zero
|
127 (12)
|
157 (19)
|
0.02
|
|
MABP (mmHg)
|
|
Baseline
|
46 (4)
|
43 (7)
|
0.69
|
|
End of insult
|
53 (8)
|
41 (6)
|
0.04
|
|
2–26 h after time zero
|
48 (3)
|
42 (3)
|
0.07
|
|
48 h after time zero
|
47 (11)
|
47 (10)
|
0.99
|
|
T rectal (°C)
|
|
Baseline
|
38.8 (0.4)
|
38.7 (0.2)
|
0.82
|
|
End of insult
|
38.5 (0.4)
|
38.5 (0.3)
|
0.11
|
|
2–26 h after time zero
|
38.6 (0.1)
|
33.4 (0.2)
|
0.04
|
|
48 h after time zero
|
38.4 (0.4)
|
38.6 (0.5)
|
0.30
|
|
pH
|
|
Baseline
|
7.49 (0.05)
|
7.50 (0.07)
|
0.39
|
|
Nadir of the insult
|
7.43(0.07)
|
7.49(0.11)
|
0.26
|
|
12 h after time zero
|
7.48(0.08)
|
7.48(0.16)
|
0.10
|
|
24 h after time zero
|
7.44(0.09)
|
7.47(0.11)
|
0.68
|
|
48 h after time zero
|
7.41(0.17)
|
7.46(0.11)
|
0.99
|
|
BE (mmol/L)
|
|
Baseline
|
6.5 (3)
|
9.1 (2.4)
|
0.46
|
|
Nadir of the insult
|
1.3 (5.8)
|
4.5 (5)
|
0.16
|
|
12 h after time zero
|
5.6 (1.3)
|
7.6 (4.1)
|
0.99
|
|
24 h after time zero
|
4.9 (2)
|
7.5 (6.2)
|
0.63
|
|
48 h after time zero
|
0.7 (3.2)
|
3 (2.9)
|
0.29
|
|
Lactate (mmol/L)
|
|
Baseline
|
2.7 (1.9)
|
2.3 (0.9)
|
0.84
|
|
Nadir of the insult
|
7.6 (2.9)
|
5.6 (2.1)
|
0.25
|
|
12 h after time zero
|
1.4 (0.3)
|
1.2 (0.5)
|
0.77
|
|
24 h after time zero
|
1.3 (0.5)
|
1.0 (0.3)
|
0.07
|
|
48 h after time zero
|
1.8 (0.9)
|
1.5 (0.4)
|
0.93
|
|
Glucose (mmol/L)
|
|
Baseline
|
7.2 (1.1)
|
7.0 (1.0)
|
0.11
|
|
Nadir of the insult
|
9.0 (1.7)
|
8.5 (1.5)
|
0.36
|
|
12 h after time zero
|
5.6 (2.3)
|
8.5 (3.5)
|
0.39
|
|
24 h after time zero
|
4.6 (1.1)
|
5.2 (0.7)
|
0.39
|
|
48 h after time zero
|
5.4 (0.6)
|
7.0 (7.8)
|
0.04
|
- Mean (SD) values are presented for each group. NT (n = 5) and HT (n = 6). Heart rate and blood pressure (mean arterial blood pressure; mmHg) data are omitted for 30 min after a saline/geoplasma bolus was administered or after cardiac arrest. Mann-Whitney analysis indicated the following in the HT group: a higher HR at 48 h (after rewarming), a lower MABP after HI (although still within the normal range), a lower temperature at 2–26 h (expected) and a higher blood glucose at 48 h
