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Table 1 Physiological variables for piglets in NT and HT groups

From: Systemic pro-inflammatory cytokine status following therapeutic hypothermia in a piglet hypoxia-ischemia model

Variables Normothermia (NT) mean (SD) Hypothermia (HT) mean (SD) p Value
Post-natal age (h) 22.9 (0.9) 23.2 (0.8) 0.84
Body weight (g) 1583 (105) 1577 (91) 0.79
HR (bpm)
 Baseline 156 (12) 156 (12) 0.10
 End of insult 219 (55) 199 (55) 0.06
 2–26 h after time zero 162 (15) 132 (10) 0.10
 48 h after time zero 127 (12) 157 (19) 0.02
MABP (mmHg)
 Baseline 46 (4) 43 (7) 0.69
 End of insult 53 (8) 41 (6) 0.04
 2–26 h after time zero 48 (3) 42 (3) 0.07
 48 h after time zero 47 (11) 47 (10) 0.99
T rectal (°C)
 Baseline 38.8 (0.4) 38.7 (0.2) 0.82
 End of insult 38.5 (0.4) 38.5 (0.3) 0.11
 2–26 h after time zero 38.6 (0.1) 33.4 (0.2) 0.04
 48 h after time zero 38.4 (0.4) 38.6 (0.5) 0.30
pH
 Baseline 7.49 (0.05) 7.50 (0.07) 0.39
 Nadir of the insult 7.43(0.07) 7.49(0.11) 0.26
 12 h after time zero 7.48(0.08) 7.48(0.16) 0.10
 24 h after time zero 7.44(0.09) 7.47(0.11) 0.68
 48 h after time zero 7.41(0.17) 7.46(0.11) 0.99
BE (mmol/L)
 Baseline 6.5 (3) 9.1 (2.4) 0.46
 Nadir of the insult 1.3 (5.8) 4.5 (5) 0.16
 12 h after time zero 5.6 (1.3) 7.6 (4.1) 0.99
 24 h after time zero 4.9 (2) 7.5 (6.2) 0.63
 48 h after time zero 0.7 (3.2) 3 (2.9) 0.29
Lactate (mmol/L)
 Baseline 2.7 (1.9) 2.3 (0.9) 0.84
 Nadir of the insult 7.6 (2.9) 5.6 (2.1) 0.25
 12 h after time zero 1.4 (0.3) 1.2 (0.5) 0.77
 24 h after time zero 1.3 (0.5) 1.0 (0.3) 0.07
 48 h after time zero 1.8 (0.9) 1.5 (0.4) 0.93
Glucose (mmol/L)
 Baseline 7.2 (1.1) 7.0 (1.0) 0.11
 Nadir of the insult 9.0 (1.7) 8.5 (1.5) 0.36
 12 h after time zero 5.6 (2.3) 8.5 (3.5) 0.39
 24 h after time zero 4.6 (1.1) 5.2 (0.7) 0.39
 48 h after time zero 5.4 (0.6) 7.0 (7.8) 0.04
  1. Mean (SD) values are presented for each group. NT (n = 5) and HT (n = 6). Heart rate and blood pressure (mean arterial blood pressure; mmHg) data are omitted for 30 min after a saline/geoplasma bolus was administered or after cardiac arrest. Mann-Whitney analysis indicated the following in the HT group: a higher HR at 48 h (after rewarming), a lower MABP after HI (although still within the normal range), a lower temperature at 2–26 h (expected) and a higher blood glucose at 48 h