Fig. 5

MAP2K5-centered gene clusters exclusively based on pathway and physical interactions. The data was filtered by eliminating colocalization, coexpression, genetic interactions, and shared protein domains from the clustering criteria, but maintaining physical and pathway interactions. Shades of red represent the level of upregulation, and green represents downregulation of each gene. Red lines represent pathway associations, and green lines represent associations based on protein physical interactions. A group attributes layout was applied to discriminate p values and scores. Scores can be also identified by the size of individual nodes. Genes grouped on the left had lower p values, and highest scores than genes on the right. Genes in the center of the left group were the ones with highest scores, or highest number of connectors