Table 2 Upstream regulators from IPA analysis
From: Proteomic analysis of aged microglia: shifts in transcription, bioenergetics, and nutrient response
Top 10 upstream regulators by p value | p value of overlap | Activated upstream regulators by z-score | z-score | Inhibited upstream regulators by z-score | z-score |
|---|---|---|---|---|---|
RICTOR | 3.55E−12 | INSR | 3.43 | MAP4K4 | −3.00 |
MYC | 3.21E−11 | IFNG | 3.37 | RICTOR | −2.84 |
Nrf1 | 1.42E−10 | IKBKB | 3.14 | VCAN | −2.00 |
NFE2L2 | 1.20E−09 | APP | 3.11 |  |  |
CD3 | 1.22E−09 | NRF1 | 2.97 |  |  |
TP53 | 7.91E−09 | TP53 | 2.58 |  |  |
HNF4A | 1.83E−08 | XBP1 | 2.56 |  |  |
INSR | 3.49E−08 | Ins1 | 2.53 |  |  |
TGFB1 | 8.12E−08 | CST5 | 2.5 |  |  |
CST5 | 1.37E−07 | Cdc42 | 2.45 |  |  |