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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Retention of normal glia function by an isoform-selective protein kinase inhibitor drug candidate that modulates cytokine production and cognitive outcomes

Fig. 2

No effect of MW150 on GFAP immunostaining. a Representative images of GFAP immunohistochemical (IHC) staining in cortex of WT or APP/PS1 KI mice treated with vehicle (veh) or MW150. b Digital quantification of GFAP in the cortex was done using the Aperio ScanScope with the entire cortex used as the region of interest. Quantification using the positive pixel algorithm showed a significant increase in GFAP staining in the KI + veh compared to WT + veh (p < 0.0001). No significant difference was found between the KI + veh compared to the KI + MW150. (F2,41) = 34.66; p < 0.0001). (n = 14 WT + veh; n = 14 KI + veh; n = 14 KI + MW150). Data are mean ± SEM. Source data is available in Additional file 2: Table S2

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