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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Retention of normal glia function by an isoform-selective protein kinase inhibitor drug candidate that modulates cytokine production and cognitive outcomes

Fig. 5

No effect of MW150 on Aβ in APP/KI mice. a Aβ and microglia volume were measured using immunofluorescent staining with 6E10 for Aβ and IBA1 for microglia. A z-stack of images were taken using confocal microscopy then were analyzed using the surface tool in Imaris software. Representative confocal images and 3D surface reconstructions with Imaris software are shown. b Aβ volume occupied by the surface reconstruction was reduced in KI + MW150; however, the decrease was not significant. The data represents average of 3–4 independent z-stacks from each mouse (n = 11 KI + veh; n = 14 KI + MW150). c PBS- and FA-soluble Aβ40 or Aβ42 levels were measured by MSD ELISA. No significant effect of MW150 treatment was found in the Aβ ELISA. (n = 11 WT + veh; n = 14 KI + veh; n = 14 KI + MW150). Data are mean ± SEM. Source data is available in Additional file 1: Table S1 and Additional file 3: Table S3

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