Fig. 7

Microglial depletion alters the neuroimmune response to acute binge ethanol withdrawal. Microglia-depleted mice were gavaged with either ethanol (6 g/kg, 25% v/v) or water and sacrificed 18 h later. a Levels of pro-inflammatory TNFα and Ccl2 transcripts were determined in whole brain mRNA. b Levels of anti-inflammatory IL-1ra, IL-10, IL-4, and Arg1 were determined in whole brain mRNA. Data are represented as mean ± SEM. *p < 0.05 Tukey’s post hoc test compared to all other groups. n = 6–8/group