From: Microglial depletion alters the brain neuroimmune response to acute binge ethanol withdrawal
 | CON | –M | E | –M + E |
---|---|---|---|---|
Microglial markers | ||||
 Iba1a, b, c | 100 ± 1A | 6 ± 0.4B | 68 ± 3C | 6 ± 1B |
 CD11ba, b, c | 100 ± 2A | 3 ± 1B | 57 ± 2C | 5 ± 1B |
 CD45a | 100 ± 7 | 52 ± 7 | 121 ± 15 | 69 ± 5 |
 MHCII | 100 ± 8 | 68 ± 22 | 67 ± 4 | 48 ± 15 |
M1 microglial markers | ||||
 CD68a, b | 100 ± 6 | 17 ± 2 | 136 ± 9 | 42 ± 4 |
 CD86a, b, c | 100 ± 1A | 2 ± 0.3B | 127 ± 6C | 5 ± 2B |
 iNOSa, b, c | 100 ± 24A | 135 ± 37A | 170 ± 37A | 812 ± 145B |
 NOX2a | 100 ± 13 | 46 ± 11 | 137 ± 14 | 51 ± 10 |
M2 microglial markers | ||||
 CD206a | 100 ± 2 | 4 ± 0.2 | 91 ± 5 | 5 ± 0.3 |
 CD163a, b | 100 ± 7 | 15 ± 3 | 127 ± 11 | 30 ± 3 |
 Arg1a, b | 100 ± 8 | 103 ± 10 | 108 ± 13 | 157 ± 11 |
 Ym1 | 100 ± 15 | 133 ± 32 | 194 ± 36 | 197 ± 57 |
Pro-inflammatory cytokines | ||||
 IL-1βb | 100 ± 6 | 95 ± 14 | 143 ± 17 | 174 ± 16 |
 TNFαa, b, c | 100 ± 8A | 68 ± 11A | 600 ± 90B | 104 ± 26A |
 IL-6b | 100 ± 9 | 92 ± 6 | 131 ± 13 | 164 ± 9 |
 Ccl2b | 100 ± 12 | 127 ± 36 | 1002 ± 308 | 355 ± 60 |
Anti-inflammatory cytokines | ||||
 IL-10b, c | 100 ± 5A | 91 ± 7A | 112 ± 11A | 152 ± 9B |
 IL-4b, c | 100 ± 7A, B | 84 ± 5A | 186 ± 10B | 291 ± 40C |
 IL-1raa, b | 100 ± 5 | 113 ± 19 | 117 ± 17 | 173 ± 16 |
 TGF-β1a | 100 ± 3 | 44 ± 3 | 107 ± 11 | 58 ± 8 |
CNS cell types | ||||
 NeuNa | 100 ± 4 | 120 ± 5 | 108 ± 5 | 125 ± 10 |
 MAP2 | 100 ± 3 | 106 ± 4 | 108 ± 4 | 102 ± 5 |
 DCXb | 100 ± 7 | 97 ± 7 | 84 ± 3 | 83 ± 6 |
 GFAPa | 100 ± 5 | 148 ± 11 | 111 ± 11 | 145 ± 10 |
 S100β | 100 ± 5 | 91 ± 5 | 91 ± 4 | 95 ± 6 |
 CNP | 100 ± 3 | 93 ± 7 | 86 ± 2 | 92 ± 7 |
 MBP | 100 ± 9 | 91 ± 6 | 84 ± 7 | 85 ± 5 |
 ICAM2b, c | 100 ± 6A | 83 ± 5A | 108 ± 11A | 144 ± 8B |
 Pecam1 | 100 ± 3 | 97 ± 4 | 103 ± 9 | 110 ± 7 |
Toll-like receptors | ||||
 TLR2a, b | 100 ± 4 | 64 ± 7 | 133 ± 8 | 94 ± 7 |
 TLR3 | 100 ± 8 | 103 ± 6 | 99 ± 3 | 100 ± 5 |
 TLR4b | 100 ± 8 | 82 ± 9 | 137 ± 11 | 125 ± 11 |
 TLR7a, b, c | 100 ± 5A | 24 ± 4B | 152 ± 6C | 38 ± 3B |
Neuron-microglia signaling | ||||
 CX3CL1a, b, c | 100 ± 3A | 93 ± 2A | 96 ± 4A | 75 ± 3B |
 CX3CR1a | 100 ± 5 | 1 ± 0.1 | 112 ± 15 | 4 ± 1 |
 CD200 | 100 ± 5 | 106 ± 5 | 102 ± 3 | 104 ± 3 |
 CD200R1 | 100 ± 16 | 70 ± 9 | 105 ± 16 | 91 ± 8 |
 CSF1 | 100 ± 2 | 120 ± 5 | 113 ± 5 | 104 ± 5 |
 CSF1Ra | 100 ± 5 | 2 ± 0.3 | 91 ± 4 | 4 ± 1 |
Neurotrophins | ||||
 BDNFa, c | 100 ± 4A, B | 101 ± 4A, B | 113 ± 6A | 86 ± 5B |
 NGF | 100 ± 6 | 103 ± 3 | 96 ± 4 | 107 ± 4 |
 NT3 | 100 ± 7 | 111 ± 9 | 96 ± 6 | 117 ± 10 |
 NT4/5a, b | 100 ± 6 | 115 ± 15 | 131 ± 10 | 176 ± 17 |
Cytokine receptors | ||||
 IL-1R1a, b | 100 ± 4 | 113 ± 8 | 130 ± 6 | 189 ± 20 |
 TNFR1b | 100 ± 2 | 101 ± 5 | 131 ± 4 | 120 ± 6 |
 TNFR2a, b | 100 ± 5 | 55 ± 2 | 124 ± 5 | 70 ± 6 |
 CCR2 | 100 ± 11 | 110 ± 21 | 131 ± 22 | 144 ± 13 |
Immediate-early genes | ||||
 c-Fos | 100 ± 6 | 99 ± 13 | 155 ± 26 | 123 ± 20 |
 EGR1 | 100 ± 9 | 96 ± 4 | 121 ± 8 | 92 ± 13 |
 Arc | 100 ± 10 | 81 ± 13 | 105 ± 17 | 75 ± 19 |
 c-Junb, c | 100 ± 7A, B | 81 ± 5A | 105 ± 5A, B | 116 ± 8B |
Apoptosis pathways | ||||
 FasLa, b, c | 100 ± 6A | 98 ± 11A | 121 ± 8A | 186 ± 20B |
 FasRb | 100 ± 3 | 107 ± 7 | 146 ± 17 | 210 ± 25 |
 TL1Ab | 100 ± 9 | 88 ± 8 | 127 ± 25 | 157 ± 12 |
 DR3a | 100 ± 5 | 71 ± 7 | 91 ± 9 | 55 ± 9 |
 TRAILb | 100 ± 5 | 108 ± 5 | 88 ± 7 | 67 ± 13 |
 DR5a | 100 ± 6 | 106 ± 5 | 91 ± 6 | 139 ± 17 |
 LTαa, b, c | 100 ± 5A | 95 ± 10A | 120 ± 19A | 233 ± 25B |
 FADD | 100 ± 3 | 98 ± 5 | 99 ± 4 | 114 ± 14 |
 Caspase-3 | 100 ± 4 | 112 ± 4 | 112 ± 4 | 130 ± 12 |
Clock genes | ||||
 Per1b | 100 ± 3 | 111 ± 8 | 155 ± 6 | 185 ± 41 |
 Per2b, c | 100 ± 8A | 123 ± 5A, B | 202 ± 7C | 147 ± 12B |
 BMAL1 | 100 ± 5 | 95 ± 5 | 104 ± 4 | 110 ± 6 |
Neurotransmitter systems | ||||
 CRFa | 100 ± 8 | 87 ± 7 | 93 ± 6 | 73 ± 7 |
 DAT | 100 ± 5 | 98 ± 7 | 92 ± 4 | 100 ± 4 |
 GluR1b | 100 ± 2 | 101 ± 4 | 123 ± 3 | 121 ± 10 |
 NPY | 100 ± 2 | 95 ± 4 | 96 ± 4 | 96 ± 3 |
Other | ||||
 Glucocorticoid Receptor | 100 ± 5 | 99 ± 3 | 96 ± 3 | 90 ± 6 |
 HMGB1 | 100 ± 4 | 103 ± 7 | 101 ± 4 | 109 ± 4 |
 COX2b | 100 ± 7 | 106 ± 5 | 140 ± 7 | 151 ± 9 |
 MMP9b | 100 ± 2 | 106 ± 7 | 125 ± 6 | 133 ± 8 |
 IL-12 | 100 ± 5 | 112 ± 7 | 99 ± 8 | 101 ± 6 |
 IL-34 | 100 ± 7 | 101 ± 6 | 96 ± 7 | 262 ± 80 |
 NLRP3a, b | 100 ± 3 | 27 ± 4 | 159 ± 22 | 57 ± 6 |
 Nogo | 100 ± 4 | 114 ± 6 | 124 ± 5 | 116 ± 3 |