Fig. 5
From: Toll-like receptor 4 in glial inflammatory responses to air pollution in vitro and in vivo
Composition and biological relevance of the two modules enriched by both nPM and LPS. Blue (a) and turquoise (b) modules, by GO. Shown above are some select GO processes of interest that are enriched in the two modules. Notably, WGCNA composed the blue module of all increased RNAs, while the turquoise module was decreased RNAs. a Many of the pathways observed in the more stringent GO analysis of SAM analysis of nPM are represented in the shared blue module. These include the TLR4 signaling pathway, NF-κB pathway, and inflammatory cytokines. b Some similar pathways to decreased RNAs by SAM are observed in the turquoise module, including DNA replication. Nodes with highlighted texted were chosen as the node that best represents the network; node colors distinguish between networks. Nodes with two colors belong to both networks. The circle size represents the number of genes enriched in the node. The width of connecting lines represents the strength of connectivity between nodes