Fig. 4

Infiltrating T cells and macrophages in the sciatic nerve are reduced by fingolimod. Pan T cell staining (a) and ED1 macrophage staining (b) of the sciatic nerve at maximum disease course (day 17). Pictures of the sciatic nerve stained again T cells (c) and macrophages (d). Left picture displays sham-treated animals and right picture displays 0.1 mg/kg fingolimod-treated animals. Two independent experiments were performed with four animals per group. One-way ANOVA (p < 0.0001) combined with Tukey’s multiple comparison test was performed to calculate statistics. *p < 0.05; **p < 0.01; ***p < 0.001