Fig. 5

CUS induced depression-like behavior in wild-type C57BL6/J mice but not in mutant P2X7-null mice. a Experimental paradigm. Wild-type C57BL6/J (WT) and mutant P2X7-null mice were exposed to CUS for 35 days. Behavioral indicators were then assessed, including (b) immobility time in forced swimming test (FST) (interaction: F _{1, 37}  = 4.501, p < 0.05; genotype: F _{1, 37}  = 6.862, p < 0.05), c rearing numbers in open-field test (OFT) (interaction: F _{1, 37}  = 6.204, p < 0.05; genotype: F _{1, 37}  = 9.971, p < 0.01), (d) total distance in open-field test (OFT) (interaction: F _1,37  = 4.918, p < 0.05), e Open-arm entrance percent in elevated plus maze test (EPM) (interaction: F _{1, 34}  = 8.381, p < 0.01), and (f) open-arm time percent in elevated plus maze test (EPM) (genotype: F _{1, 34}  = 5.194, p < 0.05). n = 8–12 per group; all data are expressed as the mean ± SEM. *p < 0.05 and **p < 0.01, comparing genotypes. ^# p < 0.05, comparing treatment