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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: YY-1224, a terpene trilactone-strengthened Ginkgo biloba, attenuates neurodegenerative changes induced by β-amyloid (1-42) or double transgenic overexpression of APP and PS1 via inhibition of cyclooxygenase-2

Fig. 6

Effects YY-1224 (YY) or Gb on Aβ (1-42)-induced oxidative burdens in the hippocampus of mice. a Aβ (1-42)-induced lipid peroxidation. b Aβ (1-42)-induced protein oxidation. Lipid peroxidation and protein oxidation were evaluated by quantitative biochemical analyses and slot blot analyses. c Aβ (1-42)-induced synaptosomal formation of reactive oxygen species. Veh vehicle for YY or Gb (10% tween-80 in sterile saline). Each value is the mean ± S.E.M of six animals. *P < 0.01 vs. COX-2 (+/+) mice treated with vehicle + Aβ (42-1); # P < 0.05, ## P < 0.01 vs. COX-2 (+/+) mice treated with vehicle + Aβ (1-42); &P < 0.05 vs. COX-2 (+/+) mice treated with Gb + Aβ (1-42) (three-way ANOVA was followed by Fisher’s LSD pairwise comparisons)

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Journal of Neuroinflammation

ISSN: 1742-2094