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Table 1 Clinical parameters of rats subjected to EAE and treated with vehicle or SMI 6877002

From: Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation

Clinical parameter Vehicle SMI 6877002 Statistics
Incidence (%) 100 100  
Survival (%) 100 100  
AUC 10.6 8.7 P = 0.0804
Mean clinical score (day 13) 2.9 2.0 P = 0.1160
Mean day of onset 11.1 11.5 P = 0.4740
Mean peak disease severity 3.4 2.9 P = 0.0184
% Body weight loss (day 12 compared to day 0) 5.4 4.7 P = 0.2636
  1. Treatment with SMI 6877002 reduced the cumulative score (AUC), the mean clinical score on day 13, and the peak disease severity compared to vehicle-treated rats. P values <0.05 were considered statistically significant, as determined by the non-parametric Mann-Whitney U test for disease scores or Student’s t test for body weight