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Table 2 Clinical parameters of mice subjected to EAE and treated with vehicle or SMI 6877002

From: Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation

Clinical parameter Vehicle SMI 6877002 Statistics
Incidence (%) 93.3 100.0  
Survival (%) 86.7 100 P = 0.1641
AUC 12.75 13.39 P = 0.3461
Mean clinical score (day 15) 2.9 2.8 P = 0.9257
Mean day of onset 12.1 12.6 P = 0.6487
Mean peak disease severity 3.4 3.3 P = 0.8853
% Body weight loss (day 16 compared to day 0) 12.2 12.1 P = 0.6548
  1. Treatment with SMI 6877002 has no significant effect on clinical parameters of EAE in mice. P values <0.05 were considered statistically significant, as determined by the log-rank test for survival, the non-parametric Mann-Whitney U test for disease scores, or Student’s t test for body weight