Fig. 6

The analogue signalling pathway of TXNIP mediated by ER stress may be a novel therapeutic target in SAH-related EBI. SAH subarachnoid haemorrhage, EBI early brain injury, ER stress endoplasmic reticulum stress, PERK protein kinase RNA-like ER kinase, IRE1α inositol-requiring enzyme-1α, eIF-2α eukaryotic translation initiation factor-2α, ATF-5 activating transcription factor 5, ChREBP carbohydrate response element-binding protein, XBP1 X-box binding protein-1, TRX thioredoxin, TXNIP thioredoxin-interacting protein, NLRP3 inflammasome nod-like receptor protein 3 inflammasome, IL-1β interleukin-1β, ASK-1 apoptosis signal-regulating kinase-1, ROS reactive oxygen species