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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Isoliquiritigenin alleviates early brain injury after experimental intracerebral hemorrhage via suppressing ROS- and/or NF-κB-mediated NLRP3 inflammasome activation by promoting Nrf2 antioxidant pathway

Fig. 1

Representative macrographs and the effects of ILG treatment on ICH-induced brain impairments (a–e). Typical macrographs (left: sham, 24 h after operation; right: 24 h after ICH induction) (a). ILG administration at the doses of 20 and 40 mg/kg at 24 and 72 h after ICH induction significantly reduced the neurological deficits assessed by a mNSS score scale (b) (n = 12 rats/group). Similarly, ILG treatment at doses of 20 and 40 mg/kg markedly alleviated the histological changes evaluated via H&E staining (c) (n = 6 rats/group) and BWC (d, e) (n = 6 rats/group) measured by the dry/wet weight method at 24 and 72 h after ICH. Scale bar = 50 and 20 μm. Values are shown as means ± SD. **p < 0.01; *’: ICH + vehicle (DMSO) vs. ICH + ILG 20 mg/kg, p < 0.01; ICH + ILG 10 mg/kg vs. ICH + ILG 20 mg/kg, p < 0.05

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Journal of Neuroinflammation

ISSN: 1742-2094