Fig. 1
From: Choroid plexus-cerebrospinal fluid route for monocyte-derived macrophages after stroke
Cortical stroke upregulates adhesion molecule and chemokine gene expression in choroid plexus (CP). a qPCR analysis of adhesion molecule and chemokine gene expression in choroid plexus (CP). The sample values from MCAO-subjected mice were normalized to and presented as fold-change relative to the corresponding uninjured mouse sample values in each plate. Measurements at different time-points after the insult using qPCR were performed on pooled CP tissue from both lateral ventricles and third and fourth ventricle except at 6 h when CP ipsi- and contralateral to the ischemic lesion were analyzed separately. Means ± SEM. Asterisk: significant difference compared to corresponding samples from uninjured animals, unpaired t test, n = 4–5. 6 h-C = 6 h contralateral and 6 h-I = 6 h ipsilateral to injury. b Expression of VCAM1 protein on ZO-1 positive CP epithelium in intact mice and at 1 day after stroke. Scale bar 100 μm (upper images), 50 μm (lower images). Arrows depict colocalization of VCAM1 with ZO-1