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Table 2 Spearman rank order correlations for PET amyloid deposition and immune profile in aMCI subjects

From: Adaptive lymphocyte profiles correlate to brain Aβ burden in patients with mild cognitive impairment

      Cerebrospinal fluid (CSF) Peripheral blood (PB)
  Age PET-PCC PET-precuneous PET-mean 42 IL6 IgG CD4 T cell % B cell % Memory B cell% Plasmab % T cell # CD4 T cell # CD4:CD8 CD4 T cell% B cell % CD4:CD8
Age   0.66** 0.54* 0.20 −0.20 0.63* −0.22 0.49* 0.29 0.39 0.60** −0.28 −0.30 −0.39 0.10 −0.32 0.07
PET-PCC (0.002)   0.49* 0.49* −0.51* 0.66* 0.20 −0.35 0.25 0.16 0.28 0.57* 0.54* −0.20 0.16 −0.28 0.12
PET-precuneous (0.013) (0.029)   0.73** −0.36 −0.45 0.002 −0.39 0.10 0.38 0.39 −0.12 −0.21 −0.22 −0.34 0.58** −0.32
PET-mean (0.39) (0.027) (<0.0001)   −0.52* −0.06 0.04 −0.31 0.09 0.56* 0.18 −0.13 −0.22 −0.05 −0.33 −0.43 −0.35
CSF | Aβ42 (0.38) (0.030) (0.14) (0.029)   0.04 0.45* 0.17 −0.17 −0.40 −0.23 0.35 0.39 0.36 0.17 0.23 0.25
CSF | IL6 (0.027) (0.038) (0.19) (0.88) (0.90)   0.17 0.68 −0.02 −0.51 −0.52 0.16 0.13 0.34 0.01 0.57 0.14
CSF | IgG (0.33) (0.44) (0.99) (0.88) (0.04) (0.62)   −0.10 −0.19 −0.39 −0.16 −0.35 −0.25 −0.01 0.29 −0.06 0.22
CSF | CD4 T cell (%) (0.047) (0.22) (0.17) (0.28) (0.52) (0.86) (0.70)   −0.46 −0.05 −0.21 0.47 0.59* 0.67** −0.09 0.28 −0.08
CSF | B cell (%) (0.21) (0.34) (0.69) (0.72) (0.46) (0.95) (0.44) (0.06)   −0.02 0.17 −0.47 −0.56* −0.18 0.09 −0.16 −0.01
CSF | memory B (%) (0.09) (0.54) (0.13) (0.02) (0.08) (0.11) (0.10) (0.85) (0.93)   0.37 0.08 0.01 −0.32 0.54* −0.34 0.63**
CSF | plasmablasts (%) (0.005) (0.28) (0.12) (0.49) (0.33) (0.10) (0.50) (0.42) (0.47) (0.11)   −0.04 −0.08 −0.49* 0.09 −0.43 −0.08
CSF | T cell (#) (0.27) (0.034) (0.68) (0.65) (0.17) (0.68) (0.17) (0.06) (0.06) (0.76) (0.87)   0.95** 0.37 −0.21 0.30 −0.08
CSF | CD4 T cell (#) (0.25) (0.046) (0.47) (0.44) (0.12) (0.74) (0.34) (0.01) (0.019) (0.99) (0.75) (<0.0001)   0.50* −0.14 0.09 −0.03
CSF | CD4:CD8 (0.13) (0.49) (0.45) (0.86) (0.15) (0.37) (0.97) (0.003) (0.49) (0.20) (0.05) (0.14) (0.04)   0.13 0.17 0.19
PB | CD4T (%) (0.68) (0.56) (0.20) (0.22) (0.48) (0.97) (0.22) (0.73) (0.72) (0.026) (0.74) (0.41) (0.60) (0.63)   0.20 0.94**
PB | B cell (%) (0.13) (0.23) (0.007) (0.06) (0.30) (0.05) (0.79) (0.28) (0.49) (0.14) (0.06) (0.24) (0.72) (0.51) (0.40)   0.18
PB | CD4:CD8 (0.76) (0.65) (0.22) (0.19) (0.31) (0.70) (0.37) (0.75) (0.99) (0.007) (0.77) (0.76) (0.91) (0.45) (<0.0001)   0.18
  1. In the rho-value section of the table, rho-values that are significant are in italics and * = <0.05 and ** = <0.01. Specific p-values are in parenthesis with significant values in italics