Fig. 5

Role of TLR4 in the passive avoidance test in the WT and TLR4-KO mice on PND 66 exposed, or not, to ethanol during the gestational and postnatal periods. Bars represent the time taken to enter the dark compartment during the passive avoidance test on the training day and during the test sessions (24 and 72 h after training). PPEE prenatal and postnatal ethanol exposure. Data are presented as mean (±SEM), n = 15 mice/group. +++p < 0.001, compared with the control WT mice during the training session; ###p < 0.001, compared with the respective group on the training day; *p > 0.05, **p < 0.01, compared with the ethanol pre-treated WT mice during the training session or the 24-h test; $p < 0.05, compared with their corresponding control pretreated group of mice on the 24-h test day