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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: microRNA dysregulation in polyglutamine toxicity of TATA-box binding protein is mediated through STAT1 in mouse neuronal cells

Fig. 1

Differential expression of Stat1 and its dependent genes. Neuro-2a cells were transfected with 16Q-TBP or 59Q-TBP and total RNA compared by microarray analysis (a) or qRT-PCR (b, c) at indicated times (24, 36, and 60 h post transfection). Relative expression indicates fold change with respect to expression at 24 h post transfection. Reporter assay for IFN-γ dependent upregulation was studied by co-transfecting GAS promoter-luciferase reporter fusion plasmid (d) in Neuro-2a cells. Induced GAS promoter activity in the presence of 59Q–TBP (e). (n = 3; *p value <0.05; **p value ≤ 0.01; ***p value ≤ 0.001)

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Journal of Neuroinflammation

ISSN: 1742-2094